Spoke 4 - Who we are - RNA Genetherapy

The University of Padua (UNIPD) has a unique cardio-metabolic research group spanning basic, translational, and clinical science. The group has world-renowned experience in cellular metabolism, mitochondrial biology, cancer and muscle metabolism, metabolic regulation of cardiovascular homeostasis and disease, as well as metabolic cross-talks among tissues, organs, and systems. The clinical group has international leadership in obesity and diabetes research, as well as the designing, promoting, and leading studies of fertilized by pre-clinical findings.

Mattia Albiero

Researcher RTD-B

Dipartimento di Scienze Chirurgiche Oncologiche e Gastroenterologiche

Annalisa Angelini

Full professor

Dipartimento di Scienze Cardio-Toraco-Vascolari e Sanità pubblica

Angelo Avogaro

Full professor

Dipartimento di Medicina

Milena Bellin

Full professor

Dipartimento di Biologia

Giovanni Di Salvo

Full professor

Dipartimento di Salute della Donna e del Bambino

Angelo Di Vincenzo

Researcher RTD-A

Dipartimento di Medicina

Gian Paolo Fadini

Full professor

Dipartimento di Medicina

Cristina Mammucari

Associate professor

Dipartimento di Scienze Biomediche

Anna Raffaello

Associate professor

Dipartimento di Scienze Biomediche

Alessandra Rampazzo

Full professor

Dipartimento di Biologia

Rosario Rizzuto

Full professor

Dipartimento di Scienze Biomediche

Vanina Natalia Romanello

Researcher RTD-B

Dipartimento di Scienze Biomediche

Marco Rossato

Associate professor

Dipartimento di Medicina

Gian Paolo Rossi

Full professor

Dipartimento di Medicina

Giacomo Rossitto

Associate professor

Dipartimento di Medicina

Marco Sandri

Full professor

Dipartimento di Scienze Biomediche

Roberto Vettor

Full professor

Dipartimento di Medicina

Carlotta Boscaro

Researcher RTD-A

Dipartimento di Medicina

Sara Coletta

Researcher RTD-A

Dipartimento di Medicina

Agnese De Mario

Researcher RTD-A

Dipartimento di Scienze Biomediche

Raphael Severino Bonadio

Research Fellow

Dipartimento di Biologia

Gemma Soler Teixidor

Research Fellow

Dipartimento di Biologia

Francesca Gasparella

Phd student

Dipartimento di Biologia

Özlem Kartal

Phd student

Dipartimento di Scienze Biomediche

Pampa Pain

Phd student

Dipartimento di Scienze Biomediche

The team has developed protein-based tolerising cardiac oligopeptides to modRNA for heart failure tolerizing vaccination experiments. The team uses an RNA antisense approach for inhibiting disease alleles in LMNA mutation and microRNAs involved in atherosclerosis.

Gianluigi Condorelli

Full professor

Giulio Stefanini

Associate professor

Marinos Kallikourdis

Researcher RTD-B

Mauro Chiarito

Researcher RTD-A

Cristina Panico

Researcher RTD-A

Davide Cao

Researcher RTD-A

Giuseppe Ferrante

Researcher RTD-A

Montserrat Climent Salarich

Researcher RTD-A

Francesca Fanuele

Phd student

Fabrizio Gianferro

Phd student

Ri.MED has a well-proven experience in single-cell RNA sequencing of cardiac progenitor cells from human diabetic patients and mouse hearts with diabetic cardiomyopathy.

Giandomenico Amico

Senior Specialist

Claudia Carcione

Technologist

Anna Paola Carreca

Scientist

Cinzia Chinnici

Principal Investigator

Maria Giovanna Francipane

Principal Investigator

Mariangela Pampalone

Senior Scientist

Simone Dario Scilabra

Principal Investigator

Filippo Calascibetta

Junior Scientist

Andrea Claudio Li Greci

Scientist

UMG participants have consolidated international leadership in stem cell biology and molecular cardiology to improve regeneration and function in diabetes mellitus and related mice models and diabetic human cardiac organoids.

Teresa Vanessa Fiorentino

Associate professor

Dipartimento di Scienze Mediche e Chirurgiche

Donatella Paolino

Full professor

Dipartimento di Medicina Sperimentale e Clinica

Massimo Fresta

Full professor

Dipartimento di Scienze della Salute

Daniele Torella

Full professor

Dipartimento di Medicina Sperimentale e Clinica

Marta Letizia Hribal

Associate professor

Dipartimento di Scienze Mediche e Chirurgiche

Giuseppe Filiberto Serraino

Associate professor

Dipartimento di Medicina Sperimentale e Clinica

Salvatore De Rosa

Full professor

Dipartimento di Scienze Mediche e Chirurgiche

Isabella Leo

Researcher RTD-A

Dipartimento di Medicina Sperimentale e clinica

Nadia Salerno

Researcher RTD-A

Dipartimento di Medicina Sperimentale e clinica

The participants of UNIBA have consolidated skills in the molecular mechanisms of non-transmissible high-prevalence diseases with an inflammatory basis, including obesity, type 2 diabetes, and their chronic complications.

Loreto Gesualdo

Full Professor

Fabio Sallustio

Associate Professor

Annalisa Natalicchio

Associate Professor

Angelo Cignarelli

Associate Professor

Francesco Giorgino

Full Professor

Paola Pontrelli

Associate Professor

Michele Vacca

Associate Professor

Antonio Moschetta

Full Professor

Ighli Di Bari

Researcher RTD-A

Nicola Marrano

Researcher RTD-A

Silvia Cultrera

Phd student

Angela Fulvia Tricase

Phd student

UNIMI has a long history of research in atherosclerosis, immunometabolic disorders, and other cardiometabolic-related syndromes. UNIMI participants are active in the study of innovative approaches to control the over-activation of the immune-inflammatory response and the metabolic reprogramming with siRNA, ASO, and other innovative techniques to determine the pharmacogenomics signature influencing siRNA therapeutics response.

Daniele Andreini

Associate professor

Dipartimento di Scienze Biomediche e Cliniche

Andrea Baragetti

Researcher RTD

Dipartimento di Scienze Farmacologiche e Biomolecolari

Fabrizia Bonacina

Researcher RTD

Dipartimento di Scienze Farmacologiche e Biomolecolari

Sara Della Torre

Researcher RTD

Dipartimento di Scienze Farmaceutiche

Giuseppe Danilo Norata

Full professor

Dipartimento di Scienze Farmacologiche e Biomolecolari

Giulio Pompilio

Associate professor

Dipartimento di Scienze Biomediche, Chirurgiche ed Odontoiatriche

Luca Valenti

Associate professor

Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti

Silvia Roda

Phd student

Farzaneh Inanloo Nigi Jak

Technologist

Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti

Annalisa Moregola

Technologist

Dipartimento di Scienze Farmacologiche e Biomolecolari

Participants from UNINA have consolidated expertise in deciphering the role of snoRNA as diagnostic and therapeutic tools in experimental models of cardiovascular pathophysiology and disease. UNINA focuses on designing the combination of miRNA/Peroxisome Proliferator-Activated Receptor (PPAR) agonists as a new therapeutic strategy for the treatment of metabolic disorders and cardiovascular diseases by identifying specific epigenetic profiles involved in the development of obesity and adipose tissue dysfunctions.

Francesco Beguinot

Full professor

Dipartimento di Scienze Mediche Traslazionali

Giovanni Esposito

Full professor

Dipartimento di Scienze Biomediche Avanzate

Pietro Formisano

Full professor

Dipartimento di Scienze Mediche Traslazionali

Anna Franzone

Associate professor

Dipartimento di Scienze Biomediche Avanzate

Armando Ialenti

Full professor

Dipartimento di Farmacia

Antonio Lavecchia

Full professor

Dipartimento di Farmacia

Michele Longo

Researcher RTD-A

Dipartimento di Scienze Mediche Traslazionali

Pasquale Maffia

Associate professor

Dipartimento di Farmacia

Cinzia Perrino

Associate professor

Dipartimento di Scienze Biomediche Avanzate

Gabriele Giacomo Schiattarella

Associate professor

Dipartimento di Scienze Biomediche Avanzate

Valentina Sepe

Associate professor

Dipartimento di Farmacia

Grazia Canciello

Researcher RTD-A

Dipartimento di Scienze Biomediche Avanzate

Fabrizio Martora

Phd student

Dipartimento di Scienze Mediche Traslazionali

Martina Ridino'

Phd student

Dipartimento di Farmacia

UNIPV participants have consolidated expertise in proposing therapeutic solutions based on RNA and novel gene therapies for cardiovascular diseases and skills to prepare therapeutic constructs and viral vectors.

Moises Di Sante

Researcher RTD-A

Dipartimento di Medicina Interna e Terapia Medica

Palma Mangione

Associate professor

Dipartimento di Medicina Molecolare

Francesca Lavatelli

Researcher RTD-A

Dipartimento di Medicina Molecolare

Francesco Pasqualini

Associate professor

Dipartimento di Ingegneria Civile e Architettura

Silvia Giuliana Priori

Full professor

Dipartimento di Medicina Molecolare

Andrea Mazzanti

Researcher RTD-B

Dipartimento di Medicina Molecolare

Sofia Giorgetti

Associate professor

Dipartimento di Medicina Molecolare

Carlo Napolitano

Associate professor

Dipartimento di Medicina Molecolare

Silvia Malinverni

Phd student

Dipartimento di Medicina Molecolare

Chiara Di Antonio

Phd student

Dipartimento di Medicina Molecolare

Chiara Marabelli

Research Fellow

Dipartimento di Medicina Molecolare

Alessandro Enrico

Researcher RTD-A

Dipartimento di Ingegneria Civile e Architettura

UNISA participants have internationally consolidated expertise in the identification of molecular regulators for the treatment of cardiovascular diseases. They have experience in multi-omics analyses to elucidate the molecular changes in biofluids and tissues and to elucidate the efficacy and safety of these novel therapies.

Carmine Vecchione

Full professor

Dipartimento di Medicina, Chirurgia ed Odontoiatria “Scuola Medica Salernitana – DIPMED

Annibale Alessandro Puca

Full professor

Dipartimento di Medicina, Chirurgia ed Odontoiatria “Scuola Medica Salernitana – DIPMED

Vicky Caponigro

Researcher RTD-A

Dipartimento di Medicina, Chirurgia ed Odontoiatria “Scuola Medica Salernitana” – DIPMED

Michele Ciccarelli

Associate professor

Dipartimento di Medicina, Chirurgia ed Odontoiatria “Scuola Medica Salernitana – DIPMED

Fabrizio Dal Piaz

Associate professor

Dipartimento di Medicina, Chirurgia ed Odontoiatria “Scuola Medica Salernitana – DIPMED

Viviana Izzo

Associate professor

Dipartimento di Medicina, Chirurgia ed Odontoiatria “Scuola Medica Salernitana – DIPMED

Roberta Tarallo

Associate professor

Dipartimento di Medicina, Chirurgia ed Odontoiatria “Scuola Medica Salernitana – DIPMED

Albino Carrizzo

Associate professor

Dipartimento di Medicina, Chirurgia ed Odontoiatria “Scuola Medica Salernitana – DIPMED

Elena Ciaglia

Researcher RTD-A

Dipartimento di Medicina, Chirurgia ed Odontoiatria “Scuola Medica Salernitana – DIPMED

Eduardo Maria Sommella

Associate professor

Dipartimento di Farmacia – DIFARMA

Simona Pace

Researcher RTD-A

Dipartimento di Farmacia – DIFARMA

Francesca Picone

Phd student

Dipartimento di Medicina, Chirurgia ed Odontoiatria “Scuola Medica Salernitana – DIPMED

UniTS will provide its well-established expertise in gene therapy, cardiomyocyte biology, and cellular/animal models of human cardiac diseases, to identify and manufacture novel RNA therapeutics for cardiovascular disorders, with the particular goal of inducing cardioprotection, neo-angiogenesis, and cardiac regeneration.