RNA - Genetherapys

BioPharma Encapsulated – Unveiling Spoke 5

Spoke 5 – Inflammatory and Infectious Diseases

Led by the University of Siena, Spoke 5 coordinates activities related to RNA-based technologies in Infectious and Inflammatory Diseases.

Spoke 5 coordinates the work of eight institutions that specialize in inflammatory and infectious diseases, immune responses, as well as coding and non-coding RNA strategies. Experts in these fields include those from Humanitas University, the University of Florence, the University of Milan, the University of Naples Federico II, the University of Padua, the University of Rome Tor Vergata, the University of Siena, and the University of Verona.

Treating and preventing inflammatory and infectious diseases has well proven effective thanks to the production of vaccines with mRNA-based technology, most notably the COVID-19 vaccines. Antigens found on the surface of cells tell our immune system whether something in our bodies is harmful or not. Some antigens are encoded by the cell itself while others occur as foreign matters such as bacteria and viruses.

What are inflammatory diseases?

Chronic inflammatory diseases are pathologies that have in common a chronic inflammatory condition associated with an abnormal immune reaction directed against an organism.

The mechanism underlying these diseases is inflammation, assessing these reactions considers both the causes, including environmental ones, and the consequences on the entire organism.  This integrated and multidisciplinary approach favors the continuity and interrelationships between different chronic inflammatory diseases.

What are infectious diseases?

Microorganisms and parasites that can enter the human body cause infectious diseases. In some cases, the immune system effectively fights these pathogens, while other pathogens succeed and cause disease. Bacteria, viruses, fungi, and parasites can cause infectious diseases.

Pathogens transmitted directly or indirectly to other individuals may carry contagious infectious diseases. In contrast, non-contagious infectious diseases require special circumstances or the intervention of specific vectors for transmission to succeed.

 

Foundation staff writer Ellen Jane Corcoran

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